{"id":272,"date":"2025-10-23T17:22:27","date_gmt":"2025-10-23T09:22:27","guid":{"rendered":"https:\/\/chemkirswell.com\/?p=272"},"modified":"2025-10-23T18:02:52","modified_gmt":"2025-10-23T10:02:52","slug":"7087-68-5","status":"publish","type":"post","link":"https:\/\/chemkirswell.com\/index.php\/2025\/10\/23\/7087-68-5\/","title":{"rendered":"N,N-\u4e8c\u5f02\u4e19\u57fa\u4e59\u80fa CAS\u53f7: 7087-68-5"},"content":{"rendered":"\n

\u5728\u6709\u673a\u5408\u6210\u5b9e\u9a8c\u5ba4\u4e2d\uff0c\u8bd5\u5242\u7684\u9009\u62e9\u76f4\u63a5\u51b3\u5b9a\u53cd\u5e94\u7684\u6210\u8d25\u4e0e\u5426\u3002\u4eca\u5929\uff0c\u6211\u4eec\u6df1\u5165\u89e3\u6790\u4e00\u6b3e\u6df1\u53d7\u5316\u5b66\u5bb6\u4fe1\u8d56\u7684\u8bd5\u5242\u2014\u2014N,N-\u4e8c\u5f02\u4e19\u57fa\u4e59\u80fa\uff08\u7b80\u79f0 DIPEA \u6216 H\u00fcnig \u78b1\uff09\u3002\u4f5c\u4e3a\u9ad8\u6548\u975e\u4eb2\u6838\u6027\u5f3a\u78b1\uff0cDIPEA \u5728\u591a\u79cd\u6709\u673a\u5408\u6210\u53cd\u5e94\u4e2d\u626e\u6f14\u4e0d\u53ef\u6216\u7f3a\u7684\u89d2\u8272\u3002<\/p>\n\n\n\n

\u4e00\u3001DIPEA \u7684\u57fa\u7840\u4fe1\u606f<\/p>\n\n\n\n

\u5316\u5b66\u540d\u79f0: N,N-\u4e8c\u5f02\u4e19\u57fa\u4e59\u80fa<\/p>\n\n\n\n

\u82f1\u6587\u540d: N,N-Diisopropylethylamine<\/p>\n\n\n\n

\u7f29\u5199: DIPEA\u3001H\u00fcnig \u78b1<\/p>\n\n\n\n

\u5206\u5b50\u5f0f: C\u2088H\u2081\u2089N<\/p>\n\n\n\n

CAS \u53f7: 7087-68-5<\/p>\n\n\n\n

\u7269\u7406\u6027\u8d28:<\/p>\n\n\n\n

\u5916\u89c2: \u65e0\u8272\u900f\u660e\u6db2\u4f53<\/p>\n\n\n\n

\u6cb8\u70b9: 127-129\u00b0C<\/p>\n\n\n\n

\u5bc6\u5ea6: 0.742 g\/mL\uff0825\u00b0C\uff09<\/p>\n\n\n\n

\u6eb6\u89e3\u6027: \u6613\u6eb6\u4e8e THF\u3001DCM\u3001\u4e59\u919a\u7b49\u6709\u673a\u6eb6\u5242\uff0c\u5fae\u6eb6\u4e8e\u6c34<\/p>\n\n\n\n

\u7ed3\u6784\u7279\u70b9:<\/p>\n\n\n\n

DIPEA \u5206\u5b50\u5305\u542b\u4e59\u80fa\u9aa8\u67b6\uff0c\u4e24\u4e2a\u5f02\u4e19\u57fa\u53d6\u4ee3\u57fa\u901a\u8fc7\u6c2e\u539f\u5b50\u8fde\u63a5\u3002\u5176\u9ad8\u5ea6\u652f\u94fe\u5316\u7ed3\u6784\u8d4b\u4e88\u5176\u5f3a\u78b1\u6027\u4e0e\u5f31\u4eb2\u6838\u6027\uff0c\u6210\u4e3a\u590d\u6742\u53cd\u5e94\u4e2d\u7684\u5173\u952e\u4f18\u52bf\u3002<\/p>\n\n\n\n

\u4e8c\u3001DIPEA \u7684\u6838\u5fc3\u4f5c\u7528<\/p>\n\n\n\n

\u4f5c\u4e3a\u975e\u4eb2\u6838\u6027\u5f3a\u78b1<\/p>\n\n\n\n

DIPEA \u7684 pKa\uff08\u7ea6 11.4\uff09\u9ad8\u4e8e\u4e09\u4e59\u80fa\uff08pKa \u2248 10.8\uff09\uff0c\u80fd\u6709\u6548\u4e2d\u548c\u53cd\u5e94\u4e2d\u4ea7\u751f\u7684\u9178\uff08\u5982 HCl\u3001HBr\uff09\uff0c\u540c\u65f6\u907f\u514d\u4eb2\u6838\u526f\u53cd\u5e94\u3002<\/p>\n\n\n\n

\u5178\u578b\u5e94\u7528:<\/p>\n\n\n\n

\u9170\u80fa\u952e\u5f62\u6210\uff1a\u4e0e HATU\u3001HBTU \u7b49\u7f29\u5408\u5242\u8054\u7528\uff0c\u52a9\u529b\u80bd\u952e\u5408\u6210\u6216\u7fa7\u9178\u4e0e\u80fa\u7684\u5076\u8054\u3002<\/p>\n\n\n\n

Suzuki \u5076\u8054\u53cd\u5e94\uff1a\u4f5c\u4e3a\u94af\u50ac\u5316\u4f53\u7cfb\u7684\u78b1\uff0c\u6fc0\u6d3b\u787c\u9178\u8bd5\u5242\u3002<\/p>\n\n\n\n

\u8131\u4fdd\u62a4\u53cd\u5e94\uff1a\u9ad8\u6548\u53c2\u4e0e Fmoc \u57fa\u56e2\u8131\u9664\uff08\u5982\u591a\u80bd\u56fa\u76f8\u5408\u6210\uff09\u3002<\/p>\n\n\n\n

\u4f5c\u4e3a\u8d28\u5b50\u6d77\u7ef5<\/p>\n\n\n\n

\u5176\u7acb\u4f53\u4f4d\u963b\u7279\u6027\u80fd\u7a33\u5b9a\u9178\u6027\u4e2d\u95f4\u4f53\uff08\u5982\u8d28\u5b50\u5316\u6d3b\u6027\u916f\uff09\uff0c\u63d0\u5347\u53cd\u5e94\u901f\u7387\u548c\u4ea7\u7387\u3002<\/p>\n\n\n\n

\u6eb6\u5242\u4e0e\u914d\u4f53\u4f5c\u7528<\/p>\n\n\n\n

\u5728\u91d1\u5c5e\u50ac\u5316\u53cd\u5e94\u4e2d\uff0cDIPEA \u4f5c\u4e3a\u5f31\u914d\u4f53\u8c03\u8282\u50ac\u5316\u5242\u6d3b\u6027\uff0c\u5176\u4f4e\u6781\u6027\u7279\u6027\u4e5f\u4f7f\u5176\u5e38\u4f5c\u4e3a\u5171\u6eb6\u5242\u3002<\/p>\n\n\n\n

\u4e09\u3001DIPEA \u7684\u7ecf\u5178\u5e94\u7528\u573a\u666f<\/p>\n\n\n\n

\u591a\u80bd\u5408\u6210<\/p>\n\n\n\n

\u5728\u591a\u80bd\u56fa\u76f8\u5408\u6210\uff08SPPS\uff09\u4e2d\uff0cDIPEA \u4e2d\u548c\u8131 Fmoc \u4fdd\u62a4\u8fc7\u7a0b\u4e2d\u91ca\u653e\u7684\u9178\u6027\u526f\u4ea7\u7269\uff08\u5982 DBU-H+\uff09\uff0c\u4fdd\u62a4\u6811\u8102\u548c\u6c28\u57fa\u9178\u3002<\/p>\n\n\n\n

\u53cd\u5e94\u793a\u4f8b: Fmoc-AA-resin + 20% \u54cc\u5576\/DMF \u2192 AA-resin + Fmoc-\u526f\u4ea7\u7269\uff08DIPEA \u7ef4\u6301\u78b1\u6027\uff09\u3002<\/p>\n\n\n\n

\u7fa7\u9178\u6d3b\u5316\u4e0e\u5076\u8054<\/p>\n\n\n\n

\u4e0e EDC\u3001HOBt \u7b49\u7f29\u5408\u5242\u8054\u7528\uff0cDIPEA \u4e2d\u548c\u751f\u6210\u7684 HCl\uff0c\u4fc3\u8fdb\u7fa7\u9178\u8f6c\u5316\u4e3a\u6d3b\u6027\u4e2d\u95f4\u4f53\uff0c\u4e0e\u80fa\u53cd\u5e94\u751f\u6210\u9170\u80fa\u3002<\/p>\n\n\n\n

\u6b65\u9aa4:<\/p>\n\n\n\n

\u7fa7\u9178 + EDC \u2192 \u6d3b\u6027\u4e2d\u95f4\u4f53<\/p>\n\n\n\n

\u6d3b\u6027\u4e2d\u95f4\u4f53 + \u80fa\uff08DIPEA \u4e2d\u548c\uff09\u2192 \u9170\u80fa<\/p>\n\n\n\n

\u91d1\u5c5e\u6709\u673a\u53cd\u5e94<\/p>\n\n\n\n

\u5728 Buchwald-Hartwig \u80fa\u5316\u7b49\u94af\u50ac\u5316\u4ea4\u53c9\u5076\u8054\u4e2d\uff0cDIPEA \u4fc3\u8fdb\u6c27\u5316\u52a0\u6210\u6216\u8fd8\u539f\u6d88\u9664\u6b65\u9aa4\u3002<\/p>\n\n\n\n

\u56db\u3001\u4e3a\u4f55\u9009\u62e9 DIPEA \u800c\u975e\u5176\u4ed6\u78b1\uff1f<\/p>\n\n\n\n

\u8bd5\u5242<\/td>\u4f18\u70b9<\/td>\u7f3a\u70b9<\/td>\u9002\u7528\u573a\u666f<\/td><\/tr>
DIPEA<\/td>\u975e\u4eb2\u6838\u6027\u3001\u9ad8\u78b1\u6027\u3001\u4f4e\u4eb2\u6838\u6027\u526f\u53cd\u5e94<\/td>\u6210\u672c\u8f83\u9ad8<\/td>\u590d\u6742\u53cd\u5e94\u3001\u9178\u654f\u611f\u4f53\u7cfb<\/td><\/tr>
\u4e09\u4e59\u80fa\uff08TEA\uff09<\/td>\u5ec9\u4ef7\u3001\u6613\u5f97<\/td>\u4eb2\u6838\u6027\u5f3a\uff0c\u53ef\u80fd\u5bfc\u81f4\u526f\u53cd\u5e94<\/td>\u7b80\u5355\u4e2d\u548c\u53cd\u5e94<\/td><\/tr>
DBU<\/td>\u8d85\u5f3a\u78b1\u6027<\/td>\u4eb2\u6838\u6027\u5f3a\u3001\u53ef\u80fd\u7834\u574f\u5e95\u7269<\/td>\u6781\u7aef\u8131\u9178\u9700\u6c42<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u8bd5\u5242\u4f18\u70b9\u7f3a\u70b9\u9002\u7528\u573a\u666fDIPEA\u975e\u4eb2\u6838\u6027\u3001\u9ad8\u78b1\u6027\u6210\u672c\u8f83\u9ad8\u590d\u6742\u53cd\u5e94\u3001\u9178\u654f\u611f\u4f53\u7cfb\u4e09\u4e59\u80fa (TEA)\u5ec9\u4ef7\u3001\u6613\u5f97\u4eb2\u6838\u6027\u5f3a\u53ef\u80fd\u526f\u53cd\u5e94\u7b80\u5355\u4e2d\u548c\u53cd\u5e94DBU\u8d85\u5f3a\u78b1\u6027\u4eb2\u6838\u6027\u5f3a\u53ef\u80fd\u7834\u574f\u5e95\u7269\u6781\u7aef\u8131\u9178\u9700\u6c42<\/p>\n\n\n\n

\u603b\u7ed3: DIPEA \u7684\u7acb\u4f53\u4f4d\u963b\u548c\u5f31\u4eb2\u6838\u6027\u4f7f\u5176\u5728\u907f\u514d\u4eb2\u6838\u526f\u53cd\u5e94\u3001\u9178\u654f\u611f\u4f53\u7cfb\u53ca\u957f\u65f6\u95f4\u7ef4\u6301\u78b1\u6027\u73af\u5883\u4e2d\u8868\u73b0\u5353\u8d8a\u3002<\/p>\n\n\n\n

\u4e94\u3001\u4f7f\u7528 DIPEA \u7684\u6ce8\u610f\u4e8b\u9879<\/p>\n\n\n\n

\u50a8\u5b58\u6761\u4ef6: \u5bc6\u5c01\u4fdd\u5b58\u4e8e\u9634\u51c9\u5e72\u71e5\u5904\uff0c\u907f\u514d\u5149\u7167\u548c\u6f6e\u6e7f\uff08\u6613\u5438\u6e7f\uff09\uff0c\u5f00\u5c01\u540e\u5145\u6c2e\u6c14\u4fdd\u62a4\u3002<\/p>\n\n\n\n

\u5b89\u5168\u64cd\u4f5c: \u5177\u6709\u523a\u6fc0\u6027\u6c14\u5473\uff0c\u9700\u5728\u901a\u98ce\u6a71\u64cd\u4f5c\uff0c\u907f\u514d\u76ae\u80a4\u6216\u773c\u775b\u63a5\u89e6\uff08\u53ef\u80fd\u707c\u4f24\uff09\u3002<\/p>\n\n\n\n

\u5e38\u89c1\u8bef\u533a:<\/p>\n\n\n\n

\u8fc7\u91cf\u4f7f\u7528\u53ef\u80fd\u5bfc\u81f4\u526f\u53cd\u5e94\uff0c\u5efa\u8bae\u7528\u91cf 1.1-2 \u5f53\u91cf\u3002<\/p>\n\n\n\n

\u4e0e\u5f3a\u9178\u76f4\u63a5\u6df7\u5408\u9700\u7f13\u6162\u52a0\u5165\uff0c\u907f\u514d\u5267\u70c8\u653e\u70ed\u3002<\/p>\n\n\n\n

\u516d\u3001DIPEA \u7684\u66ff\u4ee3\u54c1\u4e0e\u4f9b\u5e94\u5546<\/p>\n\n\n\n

\u66ff\u4ee3\u8bd5\u5242: \u7b80\u5355\u53cd\u5e94\u53ef\u7528\u4e09\u4e59\u80fa\u3001\u5421\u5576\uff0c\u4f46\u9700\u5173\u6ce8\u4eb2\u6838\u6027\u5dee\u5f02\u3002<\/p>\n\n\n\n

\u4f9b\u5e94\u5546: Sigma-Aldrich\u3001TCI\u3001\u963f\u62c9\u4e01\u7b49\u63d0\u4f9b\u9ad8\u7eaf\u5ea6 DIPEA\uff08\u5206\u6790\u7eaf \u2265 99%\uff09\u3002<\/p>\n\n\n\n

N,N-\u4e8c\u5f02\u4e19\u57fa\u4e59\u80fa\uff08DIPEA\uff09\u51ed\u501f\u5176\u72ec\u7279\u78b1\u6027\u548c\u4f4e\u4eb2\u6838\u6027\uff0c\u6210\u4e3a\u73b0\u4ee3\u6709\u673a\u5408\u6210\u4e2d\u7684\u201c\u5e55\u540e\u82f1\u96c4\u201d\u3002\u65e0\u8bba\u662f\u591a\u80bd\u5408\u6210\u3001\u91d1\u5c5e\u50ac\u5316\uff0c\u8fd8\u662f\u590d\u6742\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\uff0cDIPEA \u90fd\u52a9\u529b\u5316\u5b66\u5bb6\u7a81\u7834\u53cd\u5e94\u74f6\u9888\uff0c\u63d0\u5347\u5b9e\u9a8c\u5ba4\u6548\u7387\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5728\u6709\u673a\u5408\u6210\u5b9e\u9a8c\u5ba4\u4e2d\uff0c\u8bd5\u5242\u7684\u9009\u62e9\u76f4\u63a5\u51b3\u5b9a\u53cd\u5e94\u7684\u6210\u8d25\u4e0e\u5426\u3002\u4eca\u5929\uff0c\u6211\u4eec\u6df1\u5165\u89e3\u6790\u4e00\u6b3e\u6df1\u53d7\u5316\u5b66\u5bb6\u4fe1\u8d56\u7684\u8bd5\u5242\u2014\u2014N,N-\u4e8c\u5f02\u4e19\u57fa\u4e59\u80fa\uff08\u7b80\u79f0 DIPEA \u6216 H\u00fcnig \u78b1\uff09\u3002\u4f5c\u4e3a\u9ad8\u6548\u975e\u4eb2\u6838\u6027\u5f3a\u78b1\uff0cDIPEA \u5728\u591a\u79cd\u6709\u673a\u5408\u6210\u53cd\u5e94\u4e2d\u626e\u6f14\u4e0d\u53ef\u6216\u7f3a\u7684\u89d2\u8272\u3002 \u4e00…<\/p>\n","protected":false},"author":1,"featured_media":273,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,12],"tags":[],"class_list":["post-272","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-products","category-finechemicals"],"_links":{"self":[{"href":"https:\/\/chemkirswell.com\/index.php\/wp-json\/wp\/v2\/posts\/272","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chemkirswell.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/chemkirswell.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/chemkirswell.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/chemkirswell.com\/index.php\/wp-json\/wp\/v2\/comments?post=272"}],"version-history":[{"count":3,"href":"https:\/\/chemkirswell.com\/index.php\/wp-json\/wp\/v2\/posts\/272\/revisions"}],"predecessor-version":[{"id":279,"href":"https:\/\/chemkirswell.com\/index.php\/wp-json\/wp\/v2\/posts\/272\/revisions\/279"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chemkirswell.com\/index.php\/wp-json\/wp\/v2\/media\/273"}],"wp:attachment":[{"href":"https:\/\/chemkirswell.com\/index.php\/wp-json\/wp\/v2\/media?parent=272"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chemkirswell.com\/index.php\/wp-json\/wp\/v2\/categories?post=272"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chemkirswell.com\/index.php\/wp-json\/wp\/v2\/tags?post=272"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}